Park Sixty at 110 East 60th Street: Manhattan’s Premier Class-A Medical Office Destination
PARK SIXTY
Park Sixty, located at 110 East 60th Street between Park and Lexington Avenues, stands as the only dedicated Class-A multi-tenant medical office building in Manhattan’s Plaza District / Upper East Side — a rare asset in a market where most medical suites are retrofitted commercial offices. Supported by a robust $20+ million modernization, Park Sixty offers advanced infrastructure, modern clinical layouts, and an unbeatable Upper East Side location surrounded by major hospitals, universities, and Midtown employers.
Turn to Wexler Healthcare & Commercial Properties, the leader in healthcare real estate in New York City for over 40 years.
A Purpose-Built Medical Building in the Plaza District
Park Sixty was conceived and engineered specifically for healthcare providers who require reliable infrastructure, efficient circulation, high-load capacity, and regulatory readiness. The building includes:
Article 28–ready infrastructure
Structural steel framing with high floor-load support
Newly upgraded mechanical, electrical, and life-safety systems
Clinical-grade HVAC supported by a new rooftop cooling tower
Large, efficient floorplates
Generous ceiling heights from 11 to 16 feet
Unmatched Access via the 4, 5, and 6 Subway Lines
A major advantage of Park Sixty is its proximity to one of the most accessible transit hubs in the city. The building sits just 400 feet from the 59th Street–Lexington Avenue subway station, providing direct access to the 4, 5, and 6 lines — Manhattan’s main north-south transit spine.
A $20+ Million Renovation Built for Healthcare Excellence
Park Sixty recently completed a comprehensive capital improvement program, including:
Installation of state-of-the-art infrastructure
A fully redesigned lobby
Upgraded corridors and shared areas
A modernized Building Management System
A 24/7 attended lobby with secure keycard access
Brand-new cooling tower
Modernized passenger, service, and freight elevators
Turnkey Medical Prebuilts
Suite 1004 — 2,515 RSF
Suite 1102 — 2,775 RSF
Suite 1204 — 2,515 RSF (Proposed Prebuilt)
Multi-Tenant Full-Floor Options
Full-floor layouts demonstrate the ability to accommodate complex clinical programs including up to 12–13 exam rooms per side, dedicated labs, multiple waiting and reception areas, and extensive consult space.
A Rare Private-Entrance “Building-Within-a-Building” Opportunity — Medical and Retail Compatible
One of Park Sixty’s most exceptional features is its private entrance on East 59th Street, providing access to a 29,206 RSF multi-floor block that can function independently within the tower.
This space offers:
Independent identity and signage on 59th Street
Private circulation for patients or retail customers
Expansive, contiguous floorplates
Flexible design options supporting medical, wellness, and select retail users
Current Availability: 87,049 RSF as of November 19th, 2025
Park Sixty offers a wide range of prebuilt suites, full-floor opportunities, and custom buildouts.
Exceptional Tenant Synergy Across Specialties
Current On-Site Specialties Include:
Dermatology
Plastic & Cosmetic Surgery
Cardiology
Ophthalmology & Oculoplastics
Internal Medicine
Concierge Medicine
Sinus & Allergy
Mental Health Clinic
Hair Transplantation Clinic
Medical Lab
Major NYC Health System (5th & 6th floors)
Ambulatory Surgery Center
Med Spa
Dental Practices
Why Park Sixty Is the Market Leader
The only Class-A medical office building in the neighborhood
Purpose-built for healthcare
Article 28–ready infrastructure
Direct access to the 4, 5, and 6 subway lines
Turnkey prebuilt suites
Prime Plaza District / Upper East Side location
Retail-compatible private-entrance opportunity
High ceilings and modern systems
A unique 29,206 RSF building-within-a-building offering
Deep tenant synergy across medical and wellness specialties
Represented Exclusively by Wexler Healthcare & Commercial Properties
Contact:
Phone: 212.836.1075
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